Tumour necrosis factor gene polymorphisms are associated with COPD
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چکیده
منابع مشابه
Tumour necrosis factor gene polymorphisms are associated with COPD.
Tumour necrosis factor (TNF)-alpha has been shown to be an important factor in animal models of chronic obstructive pulmonary disease (COPD). However, human studies of TNF polymorphisms in COPD have been equivocal. Six TNF single nucleotide polymorphisms (-1031C/T, -863C/A, -857C/T, -237G/A, -308G/A and +487G/A) and their haplotypes were investigated in 423 Caucasian smokers (298 patients with ...
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BACKGROUND Tumour necrosis factor alpha (TNFalpha) is a powerful inflammatory mediator in rheumatoid and other types of inflammatory arthritis. Polymorphisms within the TNFalpha gene have previously been investigated to determine their role in the aetiopathogenesis of rheumatoid arthritis (RA), but it is unclear whether reported associations are with susceptibility to, or severity of, disease. ...
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be associated with the development of T-reg cells and/or tolerance [5, 6]. We found that HSV infection conferred protection against atopy among Finnish children only. Besides the fact that atopy is infrequent in Russian Karelia, the overall exposure to microorganisms is overwhelming and the impact of saprophytes and other pathogens may well override the possible effects of HSV on the Russian side.
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CONTEXT Alcohol is the major aetiological agent for both chronic pancreatitis and alcoholic liver disease. However, as only a minority of alcoholics develop either chronic pancreatitis or alcoholic liver disease, there are clearly genetic or environmental cofactors that determine individual susceptibility to these diseases. OBJECTIVE To determine whether polymorphisms of the TNF gene may acco...
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Tumour necrosis factor (TNF)-alpha is associated with childhood wheezing. A genetic predisposition to increased TNF-alpha production, influenced by single nucleotide gene polymorphisms, may be important. Frequencies of TNF-alpha-308G/A and lymphotoxin (LT)-alpha+252G/A polymorphisms were compared in 115 asthmatic children, 55 wheezy infants and 156 control school children from the UK. Genotype ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2008
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00100307